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BIOGRAPHICAL SKETCH
Name : Dr. Deba Prasad Mandal
Designation : Associate Professor in Zoology, West Bengal State University
Department/Institute/University: Department of Zoology
Date of Birth : 06-09-1972 Sex (M/F) M

Education (Post-Graduation onwards & Professional Career)

Sl No. / Institution Degree Awarded(Year) Field of Study
1. University of Kalyani M.Sc. 2001 Zoology
2. Jadavpur University Ph.D 2007 Tumor Immunology

A. Position and Honors
Position and Employment (Starting with the most recent employment)

Sl No. Institution Position From (Date) To (date)
1. West Bengal State University Associate Professor in Zoology (present) 04-06-2009 Till date
2. Durgapur Government College Lecturer in Zoology 28-11-2006 03-06-2009

Honors/Awards
UGC-JRF (NET-July 2001)
CSIR-JRF (NET-December 2001)
GATE (2001) [AIR – 301 Percentile- 84.36]

Professional Experience and Training relevant to the Project

The Investigator has eleven publications in the field of Tumor Biology and has research experience in the field for the last 19 years.

B. Publications (Numbers only) Twenty seven (27)
Books : Three (3) Research Papers, Reports : Ten (27) General articles : one (1)
Patents : 2 .Others (Please specify) :.NA.

Selected peer-reviewed publications ( best publications in chronological order)
1. Sarkar A, Rahaman A, Biswas I, Mukherjee G, Chatterjee S, Bhattacharjee S*, Mandal DP*. TGFβ mediated LINC00273 upregulation sponges mir200a-3p and promotes invasion and metastasis by activating ZEB1. J Cell Physiol. 2020 Feb 4. doi: 10.1002/jcp.29614. [Epub ahead of print] PMID: 32017082
2. Patra K, Jana S, Sarkar A, Mandal DP*, Bhattacharjee S*. The inhibition of hypoxia-induced angiogenesis and metastasis by cinnamaldehyde is mediated by decreasing HIF-1α protein synthesis via PI3K/Akt pathway. Biofactors. 2019 Mar 10. Biofactors. 2019 May;45(3):401-415. PubMed PMID: 30854715.
3. Jana S, Patra K, Jana J, Mandal DP*, Bhattacharjee S*. Nrf-2transcriptionally activates P21(Cip/WAF1) and promotes A549 cell survival against oxidative stress induced by H(2)O(2). Chem Biol Interact. 2018 Apr 1;285:59-68. PubMed PMID: 29486183.
4. Jana S, Jana J, Patra K, Mondal S, Bhat J, Sarkar A, Sengupta P, Biswas A,Mukherjee M, Tripathi SP, Gangwal R, Hazra J, Sangamwar AT, Mukherjee G,Bhattacharjee S*, Mandal DP*, Chatterjee S*. LINCRNA00273 promotes cancer metastasis and its G-Quadruplex promoter can serve as a novel target to inhibit cancer invasiveness. Oncotarget. 2017 Nov 17;8(66):110234-110256. PubMed Central PMCID: PMC5746379.
5. Biswas N, Khanra S, Sarkar A, Bhattacharjee S, Mandal DP, Chaudhuri A, Chakraborty S, Choudhury CR .One new azido bridged dinuclear copper (II) thiosemicarbazide complex: synthesis, DNA/protein binding, molecular docking study and cytotoxicity activity. New J. Chem., 2017,41, 12996-13011.
6. Jana S, Patra K, Mukherjee G, Bhattacharjee S*, Mandal DP*. Antitumor potential of anethole singly and in combination with cyclophosphamide in murine Sarcoma-180 transplantable tumor model. RSC Adv., 2015,5, 56549-56559.
7. Patra K, Bose S, Sarkar S, Rakshit J, Jana S, Mukherjee A, Roy A, Mandal DP*, Bhattacharjee S*. Amelioration of cyclophosphamide induced myelosuppression and oxidative stress by cinnamic acid. Chem Biol Interact. 2012 Feb 5;195(3):231-9.doi: 10.1016/j.cbi.2012.01.001. Epub 2012 Jan 21.
8. Sen GS, Mohanty S, Hossain DM, Bhattacharyya S, Banerjee S, Chakraborty J,Saha S, Ray P, Bhattacharjee P, Mandal D, Bhattacharya A, Chattopadhyay S, Das T,Sa G. Curcumin enhances the efficacy of chemotherapy by tailoring p65NFκB-p300cross-talk in favor of p53-p300 in breast cancer. J Biol Chem. 2011 Dec 9;286(49):42232-47. doi: 10.1074/jbc.M111.262295. PubMed PMID: 22013068; PubMed Central PMCID: PMC3234918.
9. Bhattacharyya S, Mandal D, Saha B, Sen GS, Das T, Sa G. Curcumin prevents tumor-induced T cell apoptosis through Stat-5a-mediated Bcl-2 induction. J Biol Chem. 2007 Jun 1;282(22):15954-64.
10. Bhattacharyya S, Mandal D, Sen GS, Pal S, Banerjee S, Lahiry L, Finke JH,Tannenbaum CS, Das T, Sa G. Tumor-induced oxidative stress perturbs nuclear factor-kappaB activity-augmenting tumor necrosis factor-alpha-mediated T-cell death: protection by curcumin. Cancer Res. 2007 Jan 1;67(1):362-70.


List maximum of five recent publications relevant to the proposed area of work.

1. Sarkar A, Rahaman A, Biswas I, Mukherjee G, Chatterjee S, Bhattacharjee S*, Mandal DP*. TGFβ mediated LINC00273 upregulation sponges mir200a-3p and promotes invasion and metastasis by activating ZEB1. J Cell Physiol. 2020 Feb 4. doi: 10.1002/jcp.29614. [Epub ahead of print] PMID: 32017082
2. Jana S, Patra K, Jana J, Mandal DP*, Bhattacharjee S*. Nrf-2transcriptionally activates P21(Cip/WAF1) and promotes A549 cell survival against oxidative stress induced by H(2)O(2). Chem Biol Interact. 2018 Apr 1;285:59-68. PubMed PMID: 29486183.
3. Jana S, Jana J, Patra K, Mondal S, Bhat J, Sarkar A, Sengupta P, Biswas A,Mukherjee M, Tripathi SP, Gangwal R, Hazra J, Sangamwar AT, Mukherjee G,Bhattacharjee S*, Mandal DP*, Chatterjee S*. LINCRNA00273 promotes cancer metastasis and its G-Quadruplex promoter can serve as a novel target to inhibit cancer invasiveness. Oncotarget. 2017 Nov 17;8(66):110234-110256. PubMed Central PMCID: PMC5746379.
4. Bhattacharyya S, Mandal D, Saha B, Sen GS, Das T, Sa G. Curcumin prevents tumor-induced T cell apoptosis through Stat-5a-mediated Bcl-2 induction. J Biol Chem. 2007 Jun 1;282(22):15954-64.
5. Bhattacharyya S, Mandal D, Sen GS, Pal S, Banerjee S, Lahiry L, Finke JH,Tannenbaum CS, Das T, Sa G. Tumor-induced oxidative stress perturbs nuclear factor-kappaB activity-augmenting tumor necrosis factor-alpha-mediated T-cell death: protection by curcumin. Cancer Res. 2007 Jan 1;67(1):362-70.
Details of patents filed and granted by the faculties in last five years:
1. US Patent Granted (No. 9, 682, 926 B2 dated 20th June 2017) on “A cancer chemotherapeutic agent/formulation, manufacture and use thereof”, for Bose Institute, Kolkata and West Bengal State University, Barasat, 24 PGS (N). Name of Inventors: 1) Dr. Subhrangsu Chatterjee, 2) Dr. Anirban Bhunia, 3) Dr. Deba Prasad Mandal, 4) Dr. Shamee Bhattacharjee.
2. Australian National Phase Patent Granted (AU 2018201532 B2 No. 2013322120 dated 5th January 2015) on “A cancer chemotherapeutic agent/formulation, manufacture and use thereof”, for Bose Institute, Kolkata and West Bengal State University, Barasat, 24 PGS (N). Name of Inventors: 1) Dr. Subhrangsu Chatterjee, 2) Dr. Anirban Bhunia, 3) Dr. Deba Prasad Mandal, 4) Dr. Shamee Bhattacharjee.
3. European Phase Patent Filed (No. 13841638.3 dated 19th March 2015) on “A cancer chemotherapeutic agent/formulation, manufacture and use thereof”, for Bose Institute, Kolkata and West Bengal State University, Barasat, 24 PGS (N). Name of Inventors: 1) Dr. Subhrangsu Chatterjee, 2) Dr. Anirban Bhunia, 3) Dr. Deba Prasad Mandal, 4) Dr. Shamee Bhattacharjee.
4. Indian patent Filed (1120/KOL/2012 A) entitled “G-QUADRUPLEX STABILIZING AGENTS AND FORMULATIONS INVOLVING THE SAME”. Filed on 22-10-2016 for Bose Institute, Kolkata and West Bengal State University, Barasat, 24 PGS (N). Name of Inventors: 1) Dr. Subhrangsu Chatterjee, 2) Dr. Anirban Bhunia, 3) Dr. Deba Prasad Mandal, 4) Dr. Shamee Bhattacharjee.
5. Indian patent Filed (640/KOL/2015) entitled “A LINC RNA00273 FOR DIAGNOSIS AND ESTIMATION OF CANCER PROGRESSION”. Filed on 22-10-2016 Name of inventors: 1, Deba Prasad Mandal, 2) Shamee Bhattacharjee, 3) Dr. Gopeswar Mukherjee, 4) Subhrangsu Chatterjee.

C. Research Support:
Ongoing Research Projects:

Sl. No. Title of Project PI/CoPI Funding Agency Amount Date of sanction and Duration
1 Using Capsaicin to target TGFbeta in premetastatic micro
environment: Aendeavor to restrict metastasis in combination with doxorubicin in 4T1cells implanted murine breast
cancer model, PI DST SERB 43.64 Nov 2019
3 years
Completed Research Projects (State only major projects of last 3 years): NA
Sl. No. Title of Project PI/Co-PI Funding Agency Amount Date of completion
1 Validation of some North East Indian traditional anti-inflammatory plants for antiproliferative, anti-angiogenic and anti-metastatic properties: In search of novel anticancer agents
Co-PI DBT-NER 37.14 2019
2 Overcoming EGFR resistant Oral Squamous Cell Carcinomas with traditional healers of Tripura – A Preclinical Study” Co-PI DBT-NER 32 lakhs 1/04/2014
3 yr.
3 An investigation into the cross-talk between transcription factors HIF-1α/2α and Nrf-2 and their modulation by the use of active ingredients of black pepper (Piper nigrum) and coriander(Coriandrum sativum). PI DBT 24.816 lakhs 29th July 2015
4 Modulation of tumor angiogenesis by the use of active ingredients of Pimpenella anisum and Coriandrum sativum in mice, a preclinical study.
Sanction No. Ref No. 37(1487)/1 1/EMR-II Co-PI CSIR, Govt. of India
Rs 15 lacs approx. 31st March 2013
5 An Investigation into the Regulation of Nrf2 transcription factor by diosgenin and 1, 8-cineole using the p53/p21 axis in lung and leukaemic cancer.
Letter No. 5/13/49/10/NCD-III, dated 30-05 -2011 Co-PI Indian Council of Medical Research, Govt. of India.
Rs 23 lacs approx. 28th February 2015
6 Investigation into the modulation of TGFb signaling by capsaicin and eugenol using the p53/p21 axis in gastric carcinoma.
BT/PR15116/GBD/27/327/2011 dated 09/03/2011 PI Department of Biotechnology, Govt. of India 37 lacs approx. 31st March 2013

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